Research- & technology-driven peptide delivery
NeoPep is an innovation-driven company specializing in the research and manufacturing of needle-free, buccal-patch peptide delivery solutions.
The problem
Peptides are among the most precise tools in medicine — and among the hardest to deliver into the blood, which leads to low efficacy. For the clinics, pharmacies and brands dispensing them, patient compliance and ease of use are a constant hassle. Two roads, two operational headaches.
Poor buccal absorption — peptides are extremely large in size, very sensitive to heat, highly unstable, and degrade quickly when exposed to enzymes in saliva and the acidic juices of the stomach. They’re also very sensitive during mixing and manufacturing.
Injections work — but the cost lands on your operation: cold‑chain storage, sharps handling and disposal, trained administration, and the adherence gap when patients avoid the needle between visits.
So we asked a simpler question:
what if the cheek could do the work of the needle?
Meet TD‑IntelGel™ buccal patch
Three engineered layers deliver the fragile peptide across the cheek and into the blood — the buccal patch is sealed at the edges so nothing is lost into saliva.
The TD‑IntelGel™ tri-layer, sealed at the edges by Muco‑SmartSeal® — shown in motion.
The TD‑IntelGel™ technology with hydrogel enables increased buccal absorption and preserves peptides within a hydrogel matrix, helping maintain molecular stability and biological activity throughout delivery.
Provides mechanical strength and sustained contact, supporting controlled peptide diffusion across the buccal membrane.
Sealed at the edges by Muco‑SmartSeal® — maintaining prolonged contact with the mucosa and preventing peptide leakage into saliva. This positions the patch securely inside the buccal cavity for reliable, uninterrupted peptide delivery.
The Delivery Challenge
Peptides have the potential to transform modern therapeutics. Delivering them efficiently has remained the industry’s greatest challenge. Existing delivery methods each solve one problem — while creating another.Peptides could transform therapeutics—but existing delivery methods each solve one problem while creating another.
Pills & Capsules
Digestive enzymes and first-pass metabolism can degrade peptides before they reach systemic circulation, limiting their effectiveness.Digestive enzymes degrade peptides before they reach circulation.
Injections
While injections improve absorption, they remain invasive, uncomfortable and often reduce long-term patient compliance.Effective, but invasive—often reducing patient compliance.
Conventional Oral Strips
Saliva exposure, limited stability and inconsistent buccal contact can reduce peptide retention and absorption.Saliva and poor contact reduce peptide absorption.
The Science Inside
TD‑IntelGel™ is more than a buccal patch—it’s an integrated peptide delivery platform. By combining a patented tri‑layer hydrogel architecture, Muco‑SmartSeal® technology and an ultra‑gentle cold manufacturing process, it preserves peptide integrity while optimizing buccal delivery.More than a buccal patch—an integrated platform that protects peptides and optimizes buccal delivery.
A patented three‑layer hydrogel that stabilizes peptides and enables controlled, consistent buccal delivery.Patented hydrogel for consistent delivery.
A proprietary seal that keeps the patch in secure buccal contact while minimizing peptide loss.Holds in place, minimizing peptide loss.
An ultra‑gentle process that preserves the structure and bioactivity of lyophilized peptides.Preserves peptide bioactivity.
Stable Lyophilized Peptides
Efficient Buccal Delivery
Injection‑Level Performance
Oral Convenience
How it works
The patch is pressed gently to the inside of the cheek. It adheres on contact.
Muco‑SmartSeal® locks it against the mucosa in a protected pocket.
The peptide crosses the thin, blood-rich buccal lining — skipping the stomach.
It enters circulation directly, avoiding first‑pass metabolism in the liver.
Comparative Performance
Comparative data shows how much of the administered peptide reaches systemic circulation across delivery formats. TD‑IntelGel™ demonstrates substantially higher relative bioavailability than conventional oral approaches.
Relative peptide bioavailability by delivery format
* Comparative delivery performance for peptides; performance may vary by peptide, formulation and study conditions.
Not simply a more convenient format — a more effective route to systemic delivery.
Explore the validation dataA substantially higher level of systemic peptide availability than conventional oral formats.
Buccal delivery helps reduce the loss associated with the gastrointestinal pathway.
Higher availability expands what may be achievable through a needle‑free peptide format.
Platform applications beyond peptides
TD‑IntelGel™ is a versatile delivery platform that reaches beyond peptides — supporting formulations across hormones, vaccines, oncology and more, all on one TD‑IntelGel™ buccal patch format you can develop and scale together with us.
Needle-free, high-bioavailability delivery of fragile, temperature-sensitive peptides — the format the platform was built and clinically tested on.
A buccal route for temperature-sensitive vaccine formulations — developed to reduce the cold-chain and sharps burden of injectables.
Stable, patient-friendly delivery for large-molecule and temperature-sensitive hormone therapies.
Exploring gentle, needle-free routes for sensitive oncology actives — developed and validated together with partners.
Built with NeoPep
Research & Insights
EducationThe six main delivery routes and how each affects peptide stability, absorption and bioavailability.
Read article
ScienceHow each route changes the barriers a peptide faces — and what that means for absorption.
Read article
ScienceA step-by-step look at how a buccal patch delivers a peptide through the cheek.
Read articleDelivered better
Bring your molecule to a delivery platform built for real-world absorption and adherence — and manufactured end to end on our patented technology.