The Science
Explore the breakthrough science behind TD-IntelGelTM, a patented platform designed to stabilize peptides and enable efficient buccal delivery beyond traditional oral methods.
A New Standard in Peptide Delivery
NeopepTM introduces TD-IntelGelTM, a patented trans-diffusion hydrogel platform engineered to deliver peptides efficiently through the buccal membrane. By placing the dissolving patch inside the cheek, peptides are absorbed directly into the bloodstream while bypassing the gastrointestinal tract and first-pass liver metabolism. This approach enhances bioavailability while preserving peptide stability and bioactivity.
The technology is further enhanced by Muco-SmartSeal®, an engineered sealing mechanism around the patch edges that maintains prolonged contact with buccal tissue and prevents peptide loss into saliva. This protective barrier reduces enzymatic degradation and wash-out into the stomach, allowing peptides to remain stable and active during delivery.
TD-IntelGelTM Technology
TD-IntelGelTM is designed as a tri-layer hydrogel buccal patch, with each layer engineered to perform a specific role in peptide stability, delivery, and absorption.
Top Hydrogel Layer – Stabilized Peptide Matrix
The top layer contains lyophilized (freeze-dried) peptides stabilized within a hydrogel structure. This layer adheres to buccal tissue and gently expands the mucosal surface, increasing permeability and allowing peptides to diffuse efficiently through the membrane.
Backing Support Layer – Structural Integrity
The backing layer provides mechanical strength and sustained pressure, supporting consistent peptide diffusion across the buccal membrane. It ensures the patch maintains proper contact and stability during delivery.
Base Adhesive Layer – Secure Buccal Attachment
The base layer contains natural inert ingredients such as cellulose, alginate, lecithin, MCT oil, and calcium carbonate, providing adhesive properties and structural support to keep the patch securely positioned in the buccal cavity.
Muco-SmartSeal® Protection
Muco-SmartSeal® technology surrounds the patch edges and creates a protective seal that:
- Prevents peptide leakage into saliva
- Protects peptides from enzymatic degradation
- Avoids wash-out into the stomach
- Maintains prolonged contact with buccal tissue
This mechanism ensures peptides remain concentrated at the absorption site, improving stability and delivery efficiency.
Advanced Peptide Stabilization
Peptides are fragile biomolecules that can rapidly degrade due to environmental exposure, moisture, heat, and enzymatic activity. TD-IntelGelTM addresses these challenges by embedding lyophilized peptides within a stabilized hydrogel matrix, maintaining their molecular structure and biological activity throughout delivery.
Efficient Buccal Delivery
The buccal mucosa offers a highly vascularized absorption pathway. TD-IntelGelTM enables peptides up to 4000 Daltons to diffuse through this membrane, delivering them directly into systemic circulation.
Benefits include:
- Bypasses gastrointestinal degradation
- Avoids first-pass liver metabolism
- Improves peptide bioavailability
- Enables non-invasive delivery
Ultra-Gentle Cold Manufacturing
TD-IntelGelTM uses a cold-temperature manufacturing process below 8°C to protect peptide integrity during production.
Key features of the process include:
Gravitational mixing that avoids direct mechanical stress
Elimination of shear stress that can damage peptides
Controlled casting of the tri-layer hydrogel structure
Precise mixing for content uniformity
This ultra-gentle process ensures peptides remain stable, intact, and biologically active throughout manufacturing and packaging.
The Future of Peptide Delivery
By combining stabilized lyophilized peptides, trans-diffusion hydrogel technology, Muco-SmartSeal® protection, and ultra-gentle cold manufacturing, NeopepTM has created a platform designed to bridge the gap between injection-level efficacy and oral convenience.
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